:Introductory Biochemistry

Chemistry 330-01, -02, -03    (CRN 473,566,567)
Class, Test Schedule (Room: SCI1 B009 - M,W,F 9 AM) Spring 2010
Instructor: Dr. Terry L. Helser Office: PS 227 Phone: 607-436-3518 
E-mail To: HELSERTL@oneonta.edu.
Text: Biochemistry, 4th Ed., 2009, Trudy & James R. McKee (Oxford University Press)  

Catalog Description: A survey of the basic biochemistry one needs to understand recent medical and biotechnological advances. The structure and functions of molecules and macromolecules in energy and genetic metabolism are studied. (LA, CW) Prerequisite: CHEM 226 or 221.

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Month & Days
_Study Topic__
Reading Assignment 
I. Life's Structure
January 20, 22
Introduction, Co-op Class
Ch. 1
Cells & Atoms 
Ch. 2
Bonds & Water
Ch. 3
February 8,10,12  
pH, Amino Acids (Model Building)
Ch. 5
Protein Structure, Sequencing
Ch. 4,6
February 17
Exam I (Wednesday,  
SCI 1 B009, 9 AM) 
February 22-26
Spring Break - No Classes
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Month & Days
II. Energy Metabolism
Reading Assignment 
March 1, 3, 5
Energy, Enzymes
Ch. 4, Ch. 6
8, 10, 12
Enzyme Kinetics
15, 17, 19
Metabolism of Sugars
Ch. 7
22, 24, 26
Krebs Cycle, Electron Transport
Ch. 8, 9
29, April 2
Ox. Phosphorylation, Lipid Structure
Ch. 10
March 31
Exam II (Wednesday, SCI 1 B9, 9 AM)
April 5-9
Spring Break - No Classes 

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Month & Days
III. Genetic Metabolism
Reading Assignment 
April 12, 14, 16
Lipid Structure, ß Oxidation 
 19, 21, 23
Nucleic Acids
Ch. 17
26, 28, 30
Ch. 18.1, 18.2
May 3, 5, 7, 10
Transcription & The Genetic Code
Ch. 19, Ch. 18.3
May 17
Final Exam (Monday, SCI 1 B9,
8 AM - 10:30 AM)
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Hourly Exams
2 x 100 pts. = 200 pts.
Scale: 90-100% 
Final Exam: 3rd & Cumulative
200 pts.
Research Paper & Class Work & Quizzes
100 pts.
Laboratory Evaluations
200 pts.
Total: 700 pts.
You may earn up to 35 points for extra credit problem sets given throughout the semester. Tests have 10% more points than listed so I can challenge the best.

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Laboratory Schedule Room: PSci 205 - Tuesday 9-Noon (Dr. Helser), 1-4 PM (w/ Dr. S. Quick) & Thursday 8:25-11:15 AM (w/ Dr. A. Green) Spring, 2010
Required Materials: Graph Ruled Lab Notebook, Safety Goggles

You can go to the second or third part of the lab schedule, lab grading procedures or general information on lab time management from here.
Month & Days
Laboratory Topic
Evaluation (Due Date)
January 21
No Lab
26, 28
Form Groups, Check In, Plan Analysis
1-Oral Progress Rpt.
February 2, 4
#1 Lab Solutions Analysis
1-Prop. (draft 1/29, 2/1), 
9, 11
Lab Solutions Analysis
1-2nd Proposal (2/12, 2/15)
16, 18
Solutions Analysis Reports
#2 Enzyme Catalyzed Reactions
1-Oral Rpt., Peer Evaluation
2-Proposal (2/19, 3/1)
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Month & Days
Laboratory Topic
Evaluation (Due Date)
Spring Break - No labs
March 2, 4
Enzyme Catalyzed Reactions

1-Final Rpt. (3/2, 3/4)

2-2nd Proposal (3/5,3/8)

9, 11
Enzyme Catalyzed Reactions
2-3rd Proposal (3/12, 3/15)
16, 18
Enzyme Catalyzed Reactions
23, 25
Enzyme Reactions Report
#3 Cholesterol Analysis
2-Oral Rpt., Final Rpt. (3/30, 4/1)
3-1st Proposal (3/26, 3/29)
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Month & Days
Laboratory Topic
Evaluation (Due Date)
30, April 1
Cholesterol Analysis
3-2nd Proposal (4/2, 4/12)
 April 6-9
Spring Break - No labs
13, 15
Cholesterol Analysis
3-2nd Proposal (4/16, 4/19)
20, 22
Cholesterol Analysis Report
Vitamin C in Foods
3-Oral Rpt.,
4-Proposal (4/23, 4/26)
27, 29
Vitamin C in Foods
3-Final Rpt. (4/27, 4/29)
May 4, 6
Vitamin C in Foods Report
The Gene Game (Check Out)
4-Oral Rpt., Final Rpt. (5/11, 5/13)
May 17
Final Exam (Monday, SCI 1 B9,
 8 AM - 10:30 AM)

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Grading Policies:
    Your point total for lab quizzes, proposals, written and oral reports will be divided by the total possible for a % of 200 points. The proposal with objective, experimental plan with detailed procedures/flow diagram, references, MSDSs and safety notes (which proves you are prepared to do each experiment safely), must be accepted by your instructor before you will be allowed to do the lab (submit by email no later than the Friday or Monday before the lab). One point /day will be subtracted for reports submitted after due dates.
    Notebooks may be collected after the labs at the instructor's whim.

Oral reports earn a maximum of 100 points, of which 80% is for the group's presentation and 20% for the individual's stage presence, poise and participation. Generally, the score is an average of the peer evaluations from other teams and the instructor's. Copies of the printed grading form are available in the library and laboratory.

Written Reports must be typed, spaced >1.5 lines, and signed by all group members to verify that they have proofread it and agree to accept the resulting grade. They must contain team member names and job titles (note major author), an objective, introduction, flow diagram/procedure, safety notes, results (essay describing data tables, diagrams and plots), discussion and reference sections. You must be credited as the major author of at least one (1) lab report during the semester. This grade will be counted individually for the author and may be added to the lab total for your group. (See grading below.) They are due one week after the oral report is presented. One point /day will be subtracted for reports submitted after due dates.
    You must be credited as the major author of at least 1 lab report and score 60% on lab evaluations to pass the course. If you miss more than 1/3 of the labs, you will earn an E for the course, no matter what your test scores total. Plagiarism (see your Handbook) will not be tolerated. College and departmental policies apply to this course.

Classroom Etiquette:
Since you have paid OSC and your instructor dearly for the class time to learn biochemistry, unrelated activities should be avoided. Eating breakfast, drinking your stimulant of choice, chatting or "texting" on PDAs or cell phones, etc. are not only rude and inconsiderate of your colleagues, but also distract you from your purpose here. Please finish bodily needs and turn off and stow all electronic and other distractions before class begins. Portable computer use will be allowed only with prior approval of the instructor, and if you sit in front of the class and type quietly. Exceptions require an Accomodation Plan from Student Disability Services (209 Alumni Hall, x2137).

Approved clothing and safety goggles must be worn when any experimental work is occurring. Doing unauthorized experiments or procedures is prohibited. If in doubt, ask the instructor. All accidents involving personal injury, however minor, must be reported immediately to the instructor. The instructor has the right to expel anyone from the laboratory without credit for unsafe or offensive behavior or dress. 

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Introductory Biochemistry 330 Lab Information
1st Week, Tuesday/Thursday lab:

Oral (group) report from prior project in 1st hour. Peer evaluation of other teams' presentations.
Receive and study the next project. Groups work on the procedures and techniques they will need, including doing trials with known materials. Ask for demonstrations of equipment and techniques. Last 1/2 hour, teams do oral brainstorming on how they will attack the problem. Turn in requests for materials, equipment needed.

2nd & 3rd Week:

On Friday/Monday, submit the group's proposal for the problem (identify your team, members' job titles, your company, objective (why), procedure, flow chart (how), safety and how to handle data) by e-mail. Must be accepted by management before you can do the lab!  - 1 point/day off project total for late or inadequate proposals.

On your lab day, turn in typed, final report on prior project. (The major author must be clearly shown.)

4th Week:
Grading: (all points are the maximum available)
Oral (group) report = 100 points
Group's proposal; Email by Friday/Monday = 10 points
Notebook, Quiz = 10 points each
Final, typed group reports = 100 points each

    Total - 1 point/day late off project total = % of 200 points total
Final, typed report you authored = 100 points

If you must miss a class, lab or group meeting, you must inform your group and instructor. Your group should decide how you can repay your responsibilities to the group. Options might be to do extra library research, proposal or report writing, computer searches or whatever the group decides is adequate repayment for the loss of your participation. If the group decides your excuse was not valid, they may consider a loss of credit as appropriate punishment, and should so inform you and the instructor. A group can fire a member who is uncooperative or unproductive. It is that member's responsibility, then, to join another team or to do all the projects alone.

Penalties, generally -1 point for each day group reports are late, will be deducted from the primary author's grade for that report, not the other group members' grades, if requested by the group in writing or by e-mail.

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If you have questions or comments, write the:
  Author of this page: Terry Helser - helsertl@oneonta.edu
  Web Coordinator: Philip S. Bidwell - bidwelps@oneonta.edu
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  Last Modified on 1/19/2010
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